Congratulations to Paul, Galen and Colin for their work on the paper “Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase”, which was recently accepted to the European Journal of Organic Chemistry. This collaboration with the Banwell Group (ANU) describes the total synthesis of the amaryllidaceae alkaloids Zephycandidine III and Lycosinine A. Contrary to an earlier study, these compounds are shown to be poor inhibitors of acetylcholinesterase.
Joe and Matt recently presented their work at the Biomolecular Machines Conference in Banff, Canada. Joe was awarded the prize for the best student talk at the conference. Joe and Matt will be spending the next few weeks working in Nobu Tokuriki’s lab at the University of British Columbia.
Colin, Thanavit, Blair and Brendon contributed to the recently published paper entitled “Mycobacterial F420H2-dependent reductases promiscuously reduce diverse compounds through a common mechanism” in Frontiers in Microbiology. This work presents the first broad survey of actinobacterial F420H2-dependent reductases as potential industrial biocatalysts by exploring the extent, as well as mechanistic and structural bases, of their substrate promiscuity. The findings of this work suggest that engineered actinobacterial F420H2-dependent reductases are promising novel biocatalysts for the facile transformation of a wide range of α,β-unsaturated compounds. Top work guys!