Congratulations to Eleanor, who published a paper entitled “Reverse evolution leads to genotypic incompatibility despite functional and active site convergence” in eLife, together with our incredible collaborator Nobuhiko Tokuriki at the University of British Columbia.
This paper shows that the evolution of a enzyme in vitro can be reversed by reversing the selection pressure, but not by reversing the substitutions originally responsible for the change in function. This shows how epistasis can make evolution phenotypically reversible, but genotypically irreversible.
JACKSON RESEARCH GROUP 