New publication

Congratulations to Nick, Peter, and Galen, whose paper “Evolution of protein quaternary structure in response to selective pressure for increased thermostability” has been published in JMB.

This paper shows that when directed evolution was used to impose selective pressure for increased thermostability in an insect carboxylesterase, stabilization was achieved by enrichment of more stable oligomeric species. This result supports the hypothesis that oligomerization is one possible evolutionary strategy for improving protein thermostability.


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