New publication

Congratulations to Eleanor, who published a paper entitled “Reverse evolution leads to genotypic incompatibility despite functional and active site convergence” in eLife, together with our incredible collaborator Nobuhiko Tokuriki at the University of British Columbia.

This paper shows that the evolution of a enzyme in vitro can be reversed by reversing the selection pressure, but not by reversing the substitutions originally responsible for the change in function. This shows how epistasis can make evolution phenotypically reversible, but genotypically irreversible.

In the media: breakthrough in blowfly resistance research

From ABC Rural:

Australian researchers say a study on insecticide resistance in flies could save the sheep industry millions of dollars.

Flies can become resistant to insecticides called organophosphates, making it harder for farmers to treat flystrike, where flies lay eggs in the sheep’s skin leading to a lingering and painful death if left untreated.

(Read more)


Image by Sally Bryant