New Nature Comms Paper

The deazaflavin cofactor F420 is involved in a range of important redox reactions in bacteria and archaea. However, there are aspects of the F420 biosynthetic pathway that remain unclear. This work presents a revised biosynthetic pathway for F420, showing that phosphoenolpyruvate, rather than 2-phospho-L-lactate, is the key intermediate during the biosynthesis of F420. A range